Reference of 722-92-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 722-92-9 as follows.
A solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwoood, [1] g, 3.9 [MMOL)] and 2, [4-DICHLOROBENZALDEHYDE] in methanol (21 mL) was stirred at ambient temperature. After 18 hours, glacial acetic acid (0.24 mL, 4.25 [MMOL)] and sodium [CYANOBOROHYDRIDE] (388 mg, 4.25 [MMOL)] were added. After stirring an additional 18 hours, the mixture was [CONCENTRATED IN VACUO] and the residue dissolved in EtOAc. The organic layer was washed several times with brine, dried [(NA2SO4),] filtered, and concentrated. Purification by flash chromatography (4: 1 hexanes/EtOAc) afforded the title compound as a white waxy solid (1.6 g, 99percent). MS (ES+) [M/Z] 418 (M+), 420 (M+2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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