Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diolOn October 23, 2017 ,《Molybdenum-Catalyzed Enantioselective Synthesis of Planar-Chiral (η5-Phosphacyclopentadienyl)manganese(I) Complexes and Application in Asymmetric Catalysis》 was published in Organometallics. The article was written by Ogasawara, Masamichi; Tseng, Ya-Yi; Uryu, Mizuho; Ohya, Naoki; Chang, Ninghui; Ishimoto, Hiroto; Arae, Sachie; Takahashi, Tamotsu; Kamikawa, Ken. The article contains the following contents:
Enantioselective desymmetrization of Cs-sym. (η5-2,5-dialkenylphospholyl)(allyldiphenylphosphine)manganese(I) dicarbonyl complexes 1 was realized by Mo-catalyzed asym. ring-closing metathesis (ARCM), and the corresponding bridged planar-chiral phosphacymantrene derivatives 2 were obtained in good yields with excellent enantioselectivity. The enantioselectivity of the ARCM reaction was strongly influenced by the structures of the phospholyl-bound alkenyl groups, and the highest enantioselectivity of up to 99% ee was achieved in the reaction of 1d,e, which possess the 2-methylpropenyl substituents at the 2- and 5-positions of the η5-phospholides. Single-enantiomeric planar-chiral 2d, which was obtained by the recrystallization of the highly enantiomerically enriched ARCM product, can serve as a chiral ligand for the Pd-catalyzed asym. allylic alkylation to show good enantioselectivity in up to 74% ee. The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol)
(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols.Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).
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