In 2011,Chemistry – An Asian Journal included an article by Shi, Ce; Chien, Chih-Wei; Ojima, Iwao. Reference of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol. The article was titled 《Synthesis of Chiral Biphenol-Based Diphosphonite Ligands and their Application in Palladium-Catalyzed Intermolecular Asymmetric Allylic Amination Reactions》. The information in the text is summarized as follows:
A library of new 2,2′-bis(diphenylphosphinoyloxy)-1,1′-binaphthyl (binapo)-type chiral diphosphonite ligands was designed and synthesized based on chiral 3,3′,5,5′,6,6′-hexasubstituted biphenols. These bop ligands have exhibited excellent efficiency in a palladium-catalyzed intermol. allylic amination reaction, which provides a key intermediate for the total synthesis of Strychnos indole alkaloids with enantiopurities of up to 96 % ee. In addition to this study using (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol, there are many other studies that have used (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Reference of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol) was used in this study.
(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Reference of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts