In 2019,Journal of Organic Chemistry included an article by Ma, Xiantao; Yu, Jing; Yan, Ran; Yan, Mengli; Xu, Qing. Recommanded Product: 3-Pyridinemethanol. The article was titled 《Promoting Effect of Crystal Water Leading to Catalyst-Free Synthesis of Heteroaryl Thioether from Heteroaryl Chloride, Sodium Thiosulfate Pentahydrate, and Alcohol》. The information in the text is summarized as follows:
It is observed the crystal water in sodium thiosulfate pentahydrate (Na2S2O3·5H2O) can promote its multicomponent reaction with heteroaryl chlorides and alcs., providing a facile, green, and specific synthesis of unsym. heteroaryl thioethers via one-step formation of two C-S bonds under catalyst-, additive-, and solvent-free conditions. Mechanistic studies suggest that the crystal water in Na2S2O3·5H2O is crucial in generating the key thiol intermediates and byproduct NaHSO4, which then catalyzes the dehydrative substitution of alcs. with thiols to afford thioethers. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 3-Pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts