The author of 《Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR》 were Tombari, Robert J.; Saunders, Carla M.; Wu, Chun-Yi; Dunlap, Lee E.; Tantillo, Dean J.; Olson, David E.. And the article was published in ACS Chemical Biology in 2019. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:
Tryptophan, an essential amino acid, is metabolized into a variety of small mols. capable of impacting human physiol., and aberrant tryptophan metabolism has been linked to a number of diseases. There are three principal routes by which tryptophan is degraded, and thus methods for measuring metabolic flux through these pathways can be used to understand the factors that perturb tryptophan metabolism and potentially to measure disease biomarkers. Here, we describe a method utilizing 6-fluorotryptophan as a probe for detecting tryptophan metabolites in ex vivo tissue samples via 19F NMR. As a proof of concept, we demonstrate that 6-fluorotryptophan can be used to measure changes in tryptophan metabolism resulting from antibiotic-induced changes in gut microbiota composition Taken together, we describe a general strategy for monitoring amino acid metabolism using 19F NMR that is operationally simple and does not require chromatog. separation of metabolites. In the part of experimental materials, we found many familiar compounds, such as Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)
Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.
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