《Curcumin mono-carbonyl analogs as potent antibacterial compounds: synthesis, biological evaluation and docking simulation study》 was written by Wijianto, B.; Ritmaleni; Purnomo, H.; Nurrochmad, A.. Category: alcohols-buliding-blocks And the article was included in Rasayan Journal of Chemistry in 2020. The article conveys some information:
The present study aims to synthesize, evaluate biol. activity, and study docking of new analog compounds I (R = H; R1 = H, Cl; R2 = H, OH, Br; R3 = H, OH; R4 = H, Br; R5 = H, F; R6 = H; RR6 = -(CH2)3-, -(CH2)2-) as antibacterial. Claisen-Schmidt method used to synthesize compds I. The new analog compounds I have antibacterial activity with IC50 values of 37.1μM, 140μM, resp.; 79μM and 117μM in the aureus; 56.6μM, 282μM, 97.6μM and 186.1μM in subtilis; 291.2μM, 1025.9μM, 679.81μM and 561.9μM in E.coli; 29.5μM, 310.5μM, 32.9μM and 130.6μM in P. aeruginosa; 66.6μM, 328.6μM, 49.3μM and 253.8μM in mutans; 97.2μM, 392.2μM, 129.6μM, and 191.6μM in faecalis; 44,811μM (A113) in C.albicans. Synthesized mono-carbonyl curcumin analog compounds I have antibacterial activity through inhibition of bacterial cell wall synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)
3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts