《One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction》 was written by Loureiro, Daniela R. P.; Soares, Jose X.; Maia, Ana; Silva, Andre M. N.; Rangel, Maria; Azevedo, Carlos M. G.; Hansen, Steffen V.; Ulven, Trond; Pinto, Madalena M. M.; Reis, Salette; Afonso, Carlos M. M.. COA of Formula: C6H7BO3This research focused onxanthone preparation one pot Suzuki coupling. The article conveys some information:
In this communication, the first time a one-pot synthesis of the xanthone scaffold based on a carbonylative Suzuki coupling was reported. Iodophenol and (2-methoxyphenyl)boronic acid were coupled under carbon monoxide, generated from a carbon monoxide surrogate. An exptl. data-based model was built to guide the reaction optimization. The optimized conditions were 1 mol% of a pincer complex as palladium catalyst, 5 equiv of K2CO3 as base, and DMF:water (7 : 3) as solvent. The robustness of the synthetic method, namely in terms of the reactants scope, was also evaluated. This approach provided the xanthone scaffold in high yields and provided a deep insight into the carbonylative Suzuki couplings. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringCOA of Formula: C6H7BO3
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