In 2022,Yang, Zeqiu; Wu, Jianbing; Wu, Keling; Luo, Jingyi; Li, Cunrui; Zhang, Jiaming; Zhao, Minglei; Mei, Tingfang; Liu, Xinqi; Shang, Bizhi; Zhang, Yihua; Zhao, Ling; Huang, Zhangjian published an article in Journal of Medicinal Chemistry. The title of the article was 《Identification of Nitric Oxide-Donating Ripasudil Derivatives with Intraocular Pressure Lowering and Retinal Ganglion Cell Protection Activities》.Category: alcohols-buliding-blocks The author mentioned the following in the article:
Based on the synergistic therapeutic effect of nitric oxide (NO) and Rho-associated protein kinase (ROCK) inhibitors on glaucoma, a new group of NO-donating ripasudil derivatives RNO-1-RNO-6 was designed, synthesized, and biol. evaluated. The results demonstrated that the most active compound RNO-6 maintained potent ROCK inhibitory and NO releasing abilities, reversibly depolymerized F-actin, and suppressed mitochondrial respiration in human trabecular meshwork (HTM) cells. Topical administration of RNO-6 (0.26%) in chronic ocular hypertension glaucoma mice exhibited significant IOP lowering and visual function and retinal ganglion cell (RGC) protection activities, superior to an equal molar dose of ripasudil. RNO-6 could be a promising agent for glaucoma or ocular hypertension, warranting further investigation. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts