《Asymmetric hydrogenation of α-hydroxy ketones with an iridium/f-amphox catalyst: efficient access to chiral 1,2-diols》 was published in Organic Chemistry Frontiers in 2017. These research results belong to Wu, Weilong; Xie, Yun; Li, Pan; Li, Xiuxiu; Liu, Yuanhua; Dong, Xiu-Qin; Zhang, Xumu. Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol The article mentions the following:
The tridentate f-amphox ligands has been successfully applied to the iridium-catalytic asym. hydrogenation of various α-hydroxy ketones RC(O)CH2OH (R = CH3CH2, 3-BrC6H4, furan-2-yl, naphthalen-2-yl, etc.) to afford the corresponding chiral 1,2-diols (S)/(R)-RCH(OH)CH2OH with excellent results (almost all products up to 99% yield and >99%ee). This catalytic system displayed extremely high activity, achieving up to 1000000 turnover number (TON). The great performance of this asym. hydrogenation procedure makes the preparation of various chiral 1,2-diols highly practical with great potential. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol)
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol
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