On July 17, 2018, Di, Anke; Xiong, Shiqin; Ye, Zhiming; Malireddi, R. K. Subbarao; Kometani, Satoshi; Zhong, Ming; Mittal, Manish; Hong, Zhigang; Kanneganti, Thirumala-Devi; Rehman, Jalees; Malik, Asrar B. published an article.Synthetic Route of 4719-04-4 The title of the article was The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation. And the article contained the following:
Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K+ channel (K2P) TWIK2 as the K+ efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6-/- macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K+ efflux channel TWIK2 in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to TWIK2 as a potential target for anti-inflammatory therapies. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4
The Article related to twik2 nlrp3 macrophage adoptive cell transfer lung inflammation, kcnk6, nlrp3 inflammasome, p2x7 receptor, twik2, inflammation, potassium channel, Immunochemistry: Immunopathology and other aspects.Synthetic Route of 4719-04-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts