On August 31, 2015, Wu, Enqi; Kim, Kyung Tae; Adidi, Sreenivas Kalyan; Lee, Young Keun; Cho, Jong Woon; Lee, Wonjae; Kang, Jong Seong published an article.Product Details of 32462-30-9 The title of the article was Enantioseparation and chiral recognition of α-amino acids and their derivatives on (-)-18-crown-6-tetracarboxylic acid bonded silica by capillary electrochromatography. And the article contained the following:
Capillary electrochromatog. was employed for enantioseparation of α-amino acids and their derivatives (-)-18-Crown-6-2,3,11,12-tetracarboxylic acid bonded on the silica was used as the chiral stationary phase and methanol/Tris-citric acid (20 mM, pH 3.0-4.5) (20:80, volume/volume) was used as mobile phase. The enantioseparation performance is discussed and structure-chiral separation relation were tried to be explained. The enantiomeric resolution was increased when the pH of the mobile phase decreased or hydrogen of amino acid was substituted with halogen. The resolution of 4-bromophenylalanine was 2.37 at pH 4.5, however, this value was increased to 3.35 at pH 3.0. Bromo- or chloro-substituted phenylalanine tended to show higher resolution than fluoro-substituted one. For fluoro-substituted phenylalanine the resolution was increased in order of 4-, 3- and 2-substituted one. α-Methyltryptamine did not show reasonable separation As the thermodn. study is a useful tool to understand the chiral recognition, the temperature effect on the enantioseparation was studied and the thermodn. parameters were calculated The most important mechanism of chiral recognition for the analytes tested could be barrier effects based on the thermodn. calculations The coefficient of determination between hydrophobicity and separation factor is 0.87, indicating favorable separation with higher hydrophobicity of amino acids. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9
The Article related to amino acid derivative enantioseparation chiral recognition capillary electrochromatog, chiral crowntetracarboxylic acid bonded silica column capillary electrochromatog, Organic Analytical Chemistry: Separations and other aspects.Product Details of 32462-30-9
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