On November 30, 2018, Li, Yong-Xin; Yang, Jia-Ying; Alcantara, Miguel; Abelian, Grigor; Kulkarni, Ashutosh; Staubli, Ursula; Foster, Aalan C. published an article.HPLC of Formula: 32462-30-9 The title of the article was Inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 are effective in in vivo models of schizophrenia and visual dysfunction. And the article contained the following:
The N-methyl-D-aspartate receptor coagonist D-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We tested inhibitors of ASCT1 and ASCT2 for their effects in rodent models of schizophrenia and visual dysfunction, which had previously been shown to be responsive to D-serine. L-4-fluorophenylglycine (L-4FPG), L-4-hydroxyPG (L-4OHPG), and L-4-chloroPG (L-4ClPG) all showed high plasma bioavailability when administered systemically to rats and mice. L-4FPG showed good brain penetration with brain/plasma ratios of 0.7-1.4; however, values for L-4OHPG and L-4ClPG were lower. Systemically administered L-4FPG potently reduced amphetamine-induced hyperlocomotion in mice, whereas L-4OHPG was 100-fold less effective and L-4ClPG inactive at the doses tested. L-4FPG and L-4OHPG did not impair visual acuity in naive rats, and acute systemic administration of L-4FPG significantly improved the deficit in contrast sensitivity in blue light-treated rats caused by retinal degeneration. The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9
The Article related to neutral amino acid transporter asct1 asct2 schizophrenia visual dysfunction, Placeholder for records without volume info and other aspects.HPLC of Formula: 32462-30-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts