Shukla, Ila; Azmi, Lubna; Rao, Ch. V.; Jawaid, Talha; Kamal, Mehnaz; Alkhamees, Osama A.; Alaseem, Ali M.; Alsanad, Saud M. published an article in 2022, the title of the article was Inclusive roles of protocetraric acid, a secondary metabolite from the common green shield lichen Flavoparmelia caperata in alcohol-induced hepatic injury.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:
Flavoparmelia caperata belongs to the family Parmeliaceae which is a huge family of lichens and comprises of species that draw much attention about pharmacol. activities. Several medicinally important compounds have been reported in this lichen. Protocetraric acid is among the major metabolites possessed by this lichen. Hence, the present study is designed to look into the more inclusive role of protocetraric acid in case of alc.-induced hepatotoxicity in rats. Thirty rats were randomly divided into six groups: Group 1 served as the control group, Group 2 received ethanol, Group 3 received F. caperata ethanolic extract (FCE) 50 mg/kg, Group 4 received FCE 100 mg/kg, Group 5 received FCE 200 mg/kg and Group 6 received Liv.52 (Standard drug). At the end of the experiment, biochem. parameters, oxidative stress markers, inflammatory mediators, caspase-3 and 8 activities were studied. The liver tissues were further examined histopathol. for localization of areas of severe hepatotoxicity. Cell viability was determined by using the MTT assay in MCF-7 and HepG2 cells. Moreover, FCE increased cell viability. Protocetraric acid, erythritol, and myo-inositol were detected in GC-MS anal. The outcomes of this study reveal that FCE may prove to be supportive in the treatment of alc.-induced hepatotoxicity and oxidative stress. Results of different markers have revealed that among all, FCE (100 mg/kg) has demonstrated the best hepatoprotective activity. It also ameliorated the morphol. changes induced by alc. These observations speak about the significance of the components of the lichen extract The corrective action of FCE in alc.-induced liver damage may be due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid
The Article related to flavoparmelia caperata alc protocetraric acid secondary metabolite hepatic injury, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts