Pourafshar, Shirin; Nicchitta, Mira; Tyson, Crystal C.; Svetkey, Laura P.; Corcoran, David L.; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; O’Connell, Thomas M.; Lin, Pao-Hwa; Scialla, Julia J. published an article in 2021, the title of the article was Urine and plasma metabolome of healthy adults consuming the DASH (dietary approaches to stop hypertension) diet: a randomized pilot feeding study.Reference of 3-Hydroxyphenylacetic acid And the article contains the following content:
We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc anal. of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 wk of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatog./mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Reference of 3-Hydroxyphenylacetic acid
The Article related to feeding urine phenolic acid plasma metabolome hypertension, dash, blood pressure, metabolomics, nutrition, polyphenols, Placeholder for records without volume info and other aspects.Reference of 3-Hydroxyphenylacetic acid
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