On August 9, 2021, Nagumo, Ryo; Matsuoka, Takumi; Iwata, Shuichi published an article.Application of 111-29-5 The title of the article was Interactions between Acrylate/Methacrylate Biomaterials and Organic Foulants Evaluated by Molecular Dynamics Simulations of Simplified Binary Mixtures. And the article contained the following:
Improving hydrophilicity is a key factor for enhancing the biocompatibility of polymer surfaces. Nevertheless, previous studies have reported that poly(2-methoxyethyl acrylate) (PMEA) surfaces demonstrate markedly better biocompatibility than more hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) surfaces. In this work, the origins of the excellent biocompatibility of the PMEA surface are investigated using mol. dynamics (MD) simulations of simplified binary mixtures of acrylate/methacrylate trimers and organic solvents, with n-nonane, 1,5-pentanediol, or 1-octanol serving as the probe organic foulants. The interactions between the acrylate/methacrylate trimers and solvent mols. were evaluated by calculating the radial distribution function (RDF), with the resulting curves indicating that the 2-methoxyethyl acrylate (MEA) trimer has a lower affinity for n-nonane mols. than the 2-hydroxyethyl methacrylate (HEMA) trimer. This result agrees with the exptl. consensus that the biocompatibility of PMEA surfaces is better than that of PHEMA surfaces, supporting the hypothesis that the affinity between an acrylate/methacrylate trimer and a foulant mol. in a simplified binary mixture is a significant factor in determining a surfaces antifouling properties. The RDF curves obtained for the other two solvent systems exhibited behavior that further highlighted the advantages of the PMEA surfaces as biocompatible polymers. In addition, the validity of employing the second virial coefficient (B2) as a predictor of antifouling properties was explored. The order of the B2 values of different binary mixtures indicated that the MEA trimers have the lowest affinities with n-nonane mols., which confirms that although PMEA is more hydrophobic than PHEMA, it exhibits better biocompatibility. This anal. demonstrates that the MEAs weaker miscibility with nonpolar foulants contributes to the excellent biocompatibility of PMEA. Thus, B2 is a promising criterion for assessing the miscibility between acrylate/methacrylate materials and nonpolar organic foulants, which indicates the potential for predicting the antifouling properties of acrylate/methacrylate polymer materials by evaluating the value of B2. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5
The Article related to methoxyethyl acrylate biomaterial binary mixture mol dynamic simulation, phema, pmea, biocompatibility, fouling, miscibility, second virial coefficient, Placeholder for records without volume info and other aspects.Application of 111-29-5
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