On July 31, 2022, Li, Yangfan; Yao, Weijie; Gao, Yanbin published an article.COA of Formula: C3H6O4 The title of the article was Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach. And the article contained the following:
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in the treatment of DPN in clin. and exptl. studies. However, the potential metabolic mechanism of TLN for the treatment of DPN is still unclear. Here the therapeutic effect of TLN on DPN was studied, and HPLC-IT-TOF/MS was used to explore the metabolic changes related to DPN and to explore the mechanism of TLN on DPN induced by high glucose. Furthermore, metabolic pathway anal. was used to explore the metabolic changes induced by DPN and TLN. As a result, TLN could improve the peripheral nerve function of DPN rats, and TLN could reduce the demyelination of the sciatic nerve in DPN rats. Metabolomics anal. showed that 14 potential biomarkers (citrate, creatine, fumarate, glyceric acid, glycine, succinate, etc.) of both DPN and TLN treatment were identified. Pathway anal. showed that the changes in these metabolites were mainly related to the citrate cycle (TCA cycle); glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4
The Article related to tang luo ning antidiabetic agent metabolome diabetic peripheral neuropathy, tang luo ning, diabetic peripheral neuropathy, metabolomics, pathway analysis, Placeholder for records without volume info and other aspects.COA of Formula: C3H6O4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts