Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H8O3, blongs to alcohols-buliding-blocks compound. COA of Formula: C4H8O3
A suspension of sodium hydride (11.2 g, 60% dispersion in mineral oil, 280 mmol) in1 ,2-dimethoxyethane (250 mL) was cooled to 000, treated dropwise with ethyl glycolate(25.5 mL, 269 mmol) and stirred at 23 00 for 30 mi Ethyl-2-chloronicotinate (20.0 g, 108 mmol) in 1,2-dimethoxyethane (40 mL) was added dropwise over 10 mm and the mixture was stirred at 70 00 for 15 hours. The solvent was evaporated, the residue dissolved in water (500 mL) and washed with toluene. The aqueous layer was acidifiedwith acetic acid (19 mL) to pH Sand extracted five times with CH2CI2 (5 x 100 mL). The combined organic layers were dried over anhydrous MgSO4, filtered and the solvent evaporated. Column chromatography (Si02 EtOAc/Heptane, 20:80 ->50:50) of the crude gave ethyl 3-hydroxyfuro[2,3-b]pyridine-2-carboxylate (21.1 g, 94%) as a yellow solid.1H NMR (400 MHz, Chloroform-o) 6 = 8.52 (dd, J= 4.9, 1.7 Hz, 1H, H-Ar), 8.12 (dd, J7.8, 1.7 Hz, 1H, H-Ar), 7.31 (dd, J= 7.8, 4.8 Hz, 1H, H-Ar), 4.47 (q, J= 7.1 Hz, 2H, 0-CH2CH3), 4.13 (s, 1H, OH), 1.44 (t, J= 7.1 Hz, 3H, 0-CH2CH3) ppm.MS (ESI+, H20/MeCN) mlz(%): 208.0 (100, [M + H]j.
The synthetic route of 623-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe David; (187 pag.)WO2018/229193; (2018); A1;,
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