Li, Ji; Pan, Weiwei; Qian, Jianqin; Ni, Yan; Fu, Junfen; Ni, Shaoqing published an article in 2022, the title of the article was Metabolomic differential compounds reflecting the clinical efficacy of polyethylene glycol recombinant human growth hormone in the treatment of childhood growth hormone deficiency.Category: alcohols-buliding-blocks And the article contains the following content:
Understanding metabolite profiles may aid in providing a reference for individualized treatment using PEG-rhGH. Therefore, this study aimed to evaluate the clin. efficacy of PEG-rhGH in treating GHD patients by using a metabolomic approach. Fifty-seven pediatric participants treated with PEG-rhGH were enrolled (28 GHD patients with high clin. efficacy and 29 GHD patients with lower clin. efficacy). Serum samples from all patients were first collected at baseline for biochem. detection; then metabolite levels were measured using gas chromatog. time-of-flight mass spectrometry. The candidates included heptadecanoic acid, stearic acid, 2-hydroxybutyric acid, myristic acid, palmitoleic acid, D-galactose, dodecanoic acid, and oleic acid. The related metabolic pathways involved fatty acid metabolism and energy metabolism This study suggested that growth gains of PEG-rhGH treatment might be differentiated by altered serum levels of fatty acid. Collectively, the metabolomic study provides unique insights into the use of PEG-rhGH as a therapeutic strategy for individualized treatment. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks
The Article related to polyethylene glycol human growth hormone deficiency energy metabolism metabolomic, peg-rhgh, biomarkers, clinical efficacy, growth hormone deficiency, metabolomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks
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