Hagenbeek, Fiona A.; van Dongen, Jenny; Pool, Rene; Harms, Amy C.; Roetman, Peter J.; Fanos, Vassilios; van Keulen, Britt J.; Walker, Brian R.; Karu, Naama; Hulshoff Pol, Hilleke E.; Rotteveel, Joost; Finken, Martijn J. J.; Vermeiren, Robert R. J. M.; Kluft, Cornelis; Bartels, Meike; Hankemeier, Thomas; Boomsma, Dorret I. published an article in 2022, the title of the article was Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children.Synthetic Route of 473-81-4 And the article contains the following content:
Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7-12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25-0.64), 0.50 (range: 0.33-0.62), and 0.64 (range: 0.43-0.81), resp. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37-0.68), 0.50 (range; 0.23-0.61), and 0.47 (range: 0.32-0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4
The Article related to steroid hormone organic acids urinary amines metabolomics, amines, children, classical twin design, heritability, metabolites, organic acids, steroid hormones, urine, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4
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