Kowalski, Piotr S.; Capasso Palmiero, Umberto; Huang, Yuxuan; Rudra, Arnab; Langer, Robert; Anderson, Daniel G. published an article in 2018, the title of the article was Ionizable amino-polyesters synthesized via ring opening polymerization of tertiary amino-alcohols for tissue selective mRNA delivery.Electric Literature of 4719-04-4 And the article contains the following content:
The utility of mRNA (mRNA) as a therapy is gaining a broad interest due to its potential for addressing a wide range of diseases, while effective delivery of mRNA mols. to various tissues still poses a challenge. This study reports on the design and characterization of new ionizable amino-polyesters (APEs), synthesized via ring opening polymerization (ROP) of lactones with tertiary amino-alcs. that enable tissue and cell type selective delivery of mRNA. With a diverse library of APEs formulated into lipid nanoparticles (LNP), structure-activity parameters crucial for efficient transfection are established and APE-LNPs are identified that can preferentially home to and elicit effective mRNA expression with low in vivo toxicity in lung endothelium, liver hepatocytes, and splenic antigen presenting cells, including APE-LNP demonstrating nearly tenfold more potent systemic mRNA delivery to the lungs than vivo-jetPEI. Adopting tertiary amino-alcs. to initiate ROP of lactones allows to control polymer mol. weight and obtain amino-polyesters with narrow mol. weight distribution, exhibiting batch-to-batch consistency. All of which highlight the potential for clin. translation of APEs for systemic mRNA delivery and demonstrate the importance of employing controlled polymerization in the design of new polymeric nanomaterials to improve in vivo nucleic acid delivery. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4
The Article related to aminopolyester synthesis tertiary amino alc mrna delivery tissue, biomaterials, messenger rna, nucleic acid delivery, polyesters, polymeric nanoparticles, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 4719-04-4
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