On November 30, 2010, Berkecz, Robert; Hyyrylaeinen, Anna R. M.; Fueloep, Ferenc; Peter, Antal; Janaky, Tamas; Vainiotalo, Pirjo; Pakarinen, Jaana M. H. published an article.Recommanded Product: 32462-30-9 The title of the article was Chiral discrimination of β-3-homo-amino acids using the kinetic method. And the article contained the following:
Chiral discrimination of seven enantiomeric pairs of β-3-homo-amino acids was studied by using the kinetic method and trimeric metal-bound complexes, with natural and unnatural α-amino acids as chiral reference compounds and divalent metal ions (Cu2+ and Ni2+) as the center ions. The β-3-homo-amino acids were selected for this study because, first of all, chiral discrimination of β-amino acids has not been extensively studied by mass spectrometry. Moreover, these β-3-homo-amino acids studied have different aromatic side chains. Thus, the emphasis was to study the effect of the side chain (electron d. of the Ph ring, as well as the difference between Ph and benzyl side chains) for the chiral discrimination. The results showed that by the proper choice of a metal ion and a chiral reference compound, all seven enantiomeric pairs of β-3-homo-amino acids could be differentiated. Moreover, it was noted that the β-3-homo-amino acids with benzyl side chains provided higher enantioselectivity than the corresponding Ph ones. However, increasing or decreasing the electron d. of the aromatic ring by different substituents in both the Ph and benzyl side chains had practically no role for chiral discrimination of β-3-homo-amino acids studied. When copper was used as the central metal, the Ph side chain containing reference mols. (S)-2-amino-2-phenylacetic acid (L-Phg) and (S)-2-amino-2-(4-hydroxyphenyl)-acetic acid (L-4′-OHPhg) gave rise to an addnl. copper-reduced dimeric fragment ion, [CuI(ref)(A)]+. The inclusion of this ion improved noticeably the enantioselectivity values obtained. Copyright © 2010 John Wiley & Sons, Ltd. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9
The Article related to chiral discrimination homo amino acid kinetic method copper nickel, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 32462-30-9
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