Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6920-22-5, name is Hexane-1,2-diol. A new synthetic method of this compound is introduced below., SDS of cas: 6920-22-5
At room temperature, to the right amount of organic solvent (volume ratio 4:1 of the 1,4-dioxane and polyethylene glycol 200 (PEG-200) mixture), add 100mmol said formula (I) compound, 150mmol said formula (II) compound, 140mmol said formula (III) compound, 10mmol catalyst (2mmol 1-(1-ferrocenylethyl)-3-isopropyl-1-imidazolium iodide and 8mmol nickel chloride mixture), 200mmol oxidant copper chromite (Cr2Cu2O5), 120mmol base N,N-dimethylethanolamine (DMEA) and 10mmol promoter tetraphenylporphyrin, then heat up to 70 C, and at this temperature the stirring reaction 12 hours;After the reaction, the filtering net filtering, the filtrate pH value is adjusted to the neutral, and then saturated sodium carbonate aqueous solution for washing, adding acetone extraction of 2 – 3 times, the combined organic phase, concentrated under reduced pressure, the residue over 300 – 400 mesh silica gel column chromatography, for the volume ratio of 1:2 of the mixture of ethyl acetate and petroleum ether elution, so as to obtain the compound of formula (IV), and the yield is 92.9%.
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Reference:
Patent; Liu, Zhihua; (11 pag.)CN106083917; (2016); A;,
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