On January 8, 2021, Zhou, Yaming; Ling, Yun; Deng, Mingli; Jia, Yu; Liu, Xiaofeng; Yang, Yongtai published a patent.Computed Properties of 386704-04-7 The title of the patent was Microwave synthesis method of trifluoromethyl picolinaldehyde. And the patent contained the following:
The present invention relates to a microwave synthesis method of trifluoromethyl picolinaldehyde. The preparation method comprises the following steps of reacting in a reaction tank by using a microwave irradiation technol., calculating according to a chem. equivalent ratio, adding 1 equiv of 6-trifluoromethylpicolinaldehyde methanol, adding a solvent to dissolve, adding 0.01-0.1 equiv of a catalyst and 1-1.5 equiv of an oxidant and setting microwave power and temperature to react after the feeding is finished and after the reaction is finished, carrying out rotary evaporation and concentration on the reaction solution to obtain a solid product and finally carrying out separation and purification to obtain the target 6-trifluoromethyl picolinaldehyde. The inventive method has the advantages of short reaction time, mild conditions, few side reactions and high yield, simplifies the production process, reduces the production cost and cycle and is particularly suitable for the large-scale production of the intermediate 6-trifluoromethyl nicotinaldehyde of a colony stimulating factor 1 receptor (CSF-1R) inhibitor. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Computed Properties of 386704-04-7
The Article related to trifluoromethylpyridine methanol oxidation, trifluoromethyl picolinaldehyde preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 386704-04-7
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