On June 5, 2003, Aranapakam, Venkatesan; Davis, Jamie M.; Grosu, George T.; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I.; Sandanayaka, Vincent P.; Du, Mila; Skotnicki, Jerauld S.; DiJoseph, John F.; Sung, Amy; Sharr, Michele A.; Killar, Loran M.; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao published an article.Formula: C8H19NO2 The title of the article was Synthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis. And the article contained the following:
A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Formula: C8H19NO2
The Article related to arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C8H19NO2
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