On July 4, 2013, Xiao, Dengming; Zhu, Li; Hu, Yuandong; Yu, Rong; Hu, Wei; Zhao, Na; Peng, Yong; Luo, Hong; Han, Yongxin published a patent.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of ethylene derivatives as selective estrogen receptor regulators. And the patent contained the following:
The invention relates to ethylene derivatives I [wherein R0 and R1 = independently H, halo, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; A and B = independently aryl or heteroaryl; R2 and R3 = independently halo, hydroxy, amino, cyano, mercapto, carboxyl, alkyl, alkenyl, alkynyl, etc.; m and n = independently 0-3], pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, or prodrugs thereof as selective estrogen receptor modulators (SERMs) for treating atrophic vaginitis, endometriosis, female sex dysfunction, mammary cancer, depression, diabetes mellitus, osteoporosis, etc. For example, II was prepared in a multi-step synthesis. II showed inhibitory activity with IC50 < 100 nM against MCF-7 human breast cancer cell lines. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride
The Article related to preparation pyridine pyrimidine selective estrogen receptor regulator human, treatment vaginitis endometriosis mammary cancer depression diabetes osteoporosis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride
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