On November 20, 2002, Bazylak, Grzegorz; Nagels, Luc J. published an article.Name: 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Potentiometric detection of N,N’-diethylaminoethanol and lysosomotropic amino alcohols in cation-exchange high-performance liquid-chromatography systems. And the article contained the following:
Potentiometric detection of N,N’-diethylaminoethanol (DEAE) and a series of related physiol. relevant lysosomotropic amino alcs. was carried out by cation-exchange HPLC. Poly(vinyl chloride) (PVC)-based liquid membrane electrode coatings were used which contained the lipophilic cation exchanger tetrakis(p-chlorophenyl)borate (TCPB) either alone or in combination with one of the macrocyclic ionophores hexakis-(2,3,6-tri-O-octyl)-α-cyclodextrin (CDX), dibenzo-18-crown-6 (CRW) or calix[6]arene hexaethylacetate ester (CLX). With all the PVC membrane electrodes used, improved sensitivity over UV detection at 210 nm was obtained for the aliphatic amino alcs. analyzed. Especially, addition of CLX to the PVC-based membrane led to highly enhanced detection limits for the lower-mol.-weight lysosomotropic amino compounds, i.e., aminoethanol and methylamine. The performance of the proposed potentiometric detection method was demonstrated in cation-exchange HPLC modes employing two different aqueous mobile phase systems with pH 2.30 comprising H3PO4 or HOAc with MeCN as organic modifier. Detection limits of 1.1 × 10-8 and 2.4 × 10-8M (injected concentrations) were achieved for N-methylaminoethanol and hexylamine, resp., by using a CLX-based electrode. Sensitive and reliable determination of DEAE, a local anesthetic agent, after liquid-liquid or solid-phase extraction from fortified bovine serum samples was obtained with the HPLC method coupled with the proposed potentiometric detection system. A linear free-energy relationship based on a general solvation equation was used to predict detection limits of amino alcs. from their mol. structure in the potentiometric detectors employing CLX and CRW. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Name: 2,2′-(tert-Butylazanediyl)diethanol
The Article related to amino alc determination hplc potentiometry, diethylaminoethanol determination blood liquid chromatog potentiometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 2,2′-(tert-Butylazanediyl)diethanol
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