On November 30, 2008, Henriks-Eckerman, Maj-Len; Suuronen, Katri; Jolanki, Riitta published an article.Synthetic Route of 4719-04-4 The title of the article was Analysis of allergens in metalworking fluids. And the article contained the following:
Background: Metalworking fluids (MWFs) are well-known causes of occupational contact dermatitis in machinists. Objective: To gain information about skin sensitizers in MWFs and to compare it with the information in safety data sheets (SDSs). Methods: A total of 17 samples of MWF concentrates were analyzed for skin sensitizers known or suspected to be used in MWF. Alkanolamines, formaldehyde, isothiazolinones, methyldibromo glutaronitrile (MDBGN), and iodopropynyl butylcarbamate (IPBC) were separated by liquid chromatog. Resin acids of colophonium (colophony) were separated by gas chromatog. The substances were identified with mass spectrometric detection and UV detection. Results: Of the MWFs, 15 contained 6-39% of alkanolamines, mostly monoethanolamine and triethanolamine. Formaldehyde was detected in all MWFs: the concentrations of total formaldehyde ranged between 0.002% and 1.3%. Benzisothiazolinone and octylisothiazolinone were detected in one fluid each. IPBC was detected in nine MWFs, and the highest concentration was 0.09%. Methylisothiazolinone and MDBGN were not detected in any of the fluids. Resin acids of colophonium were detected in seven MWFs in concentrations ranging from 0.41% to 3.8%. On the whole, the allergens analyzed were poorly declared in the SDSs. Conclusions: The content of total formaldehyde was not declared in any SDS. IPBC, a relatively new allergen, seems to be common in MWFs. Isothiazolinones may be relevant allergens of machinists, and they should be analyzed in MWFs in case other sources are not identified. The occupational relevance of pos. patch test results to MWF ingredients in machinists is difficult to determine if information in the SDSs is relied upon. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4
The Article related to metalworking fluid allergen, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Synthetic Route of 4719-04-4
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