On November 30, 1995, Hermansky, Steven J.; Neptun, Douglas A.; Weaver, Elizabeth V.; Ballantyne, Bryan published an article.Related Products of 2160-93-2 The title of the article was Clinical pathology changes related to cutaneous irritation in the Fischer 344 rat and New Zealand White rabbit. And the article contained the following:
An evaluation of 27 repeated dose cutaneous application studies (9 applications of 6 h over an 11-day period) indicated that several hematol. and clin. chem. parameters may be altered by chem. induced skin irritation. Irresp. of species, values that were generally decreased included Hb concentration, hematocrit, erythrocyte count, and serum concentrations of calcium, potassium, inorganic phosphorus, and creatinine. Values that were increased included the neutrophil and total leukocyte counts. Some species differences were seen; for example, while the platelet count and serum globulin concentration were increased in rabbits only, the serum glucose, sodium, and chloride concentrations were increased in rats only. The mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and serum albumin and total protein concentrations were variably affected. Changes were generally well associated with the degree of cutaneous irritation, but did not appear to be related to the chem. class of the test substances, decreased food consumption, loss of body weight, or systemic toxicity of the chem. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Related Products of 2160-93-2
The Article related to chem toxicity cutaneous irritation pathol, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Related Products of 2160-93-2
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