Reference of 37585-16-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
A suspension of (2-amino-4-chlorophenyl)methanol (5.9 g) in ethyl acetate (100 ml_) was heated until the former dissolved. Acetic anhydride (8 ml_) was added and the mixture removed from the heat. The precipitate was filtered to give a white solid and the filtrate was concentrated and slurried with hexane and filtered to give further white solid. The two batches were combined to give 5.3 g of the alcohol intermediate. The first phase of the experiment was repeated on 3x the scale described above. 21 g of the combined products was dissolved in DCM (65OmL) and added to a solution of thionyl chloride (23 ml_) in DCM (225 ml_) at room temperature under argon. The mixture was stirred for 30 minutes and concentrated to give a yellow/red solid. The solid was dissolved in DCM (500 ml_), washed with saturated sodium bicarbonate (200 ml_) and dried over magnesium sulfate. Removal of the solvent gave the 22 g of the title compound as a yellow/brown solid. 1H NMR (CDCI3) delta 8.01 (d, 1 H), 7.52 (br. s, 1 H), 7.23 (d, 1 H), 7.12 (dd, 1 H), 4.58 (s, 2H), 2.25 (s, 3H).
According to the analysis of related databases, 37585-16-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMTED; WO2007/14054; (2007); A2;,
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