Related Products of 10488-69-4, Adding some certain compound to certain chemical reactions, such as: 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate,molecular formula is C6H11ClO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10488-69-4.
A solution of 8.26 g of glycine, 12.2 g of sodium carbonate, 0.85 g of catalyst 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) was added to 200 mL of tetrahydrofuran and stirred at 40-50 ¡ã C ,16.7 g (100 mol) of ethyl (S) -3-hydroxy-4-chlorobutyrate dissolved in 50 mL of tetrahydrofuran was slowly added,After dripping,After maintaining the reaction at 48 ¡ã C for 0.5 hour,The temperature was raised to 77 ¡ã C to continue the reaction for 5 hours,After completion of the reaction, the reaction solution was cooled to room temperature,Filter out insoluble matter,Vacuum recovery of most of the organic solvent recovery,Add water to the residue,Sodium hydroxide solution to adjust the reaction solution pH to 8.5,Extracted with ethyl acetate,Water dilute hydrochloric acid to adjust the pH to 1.6,Ethyl acetate extraction,Dried and concentrated to 14.9 g of a white solid (S) -4-hydroxy-2-oxo-1-pyrrolidine acetic acid,Yield 93.6percent (calculated as ethyl (S) -3-hydroxy-4-chlorobutyric acid ethyl ester)HPLC purity 95.80percent (area normalization).
According to the analysis of related databases, 10488-69-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Murderson Biopharmaceutical Co., LTd.; Li, Zhongjun; Han, Bo; Niu, Huaying; Liu, Fanlei; (10 pag.)CN106397294; (2017); A;,
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