Rima, Maya; Trognon, Jeanne; Latapie, Laure; Chbani, Asma; Roques, Christine; El Garah, Fatima published an article in 2022, the title of the article was Seaweed Extracts: A Promising Source of Antibiofilm Agents with Distinct Mechanisms of Action against Pseudomonas aeruginosa.Application In Synthesis of 2,4-Di-tert-butylphenol And the article contains the following content:
The organization of bacteria in biofilms is one of the adaptive resistance mechanisms providing increased protection against conventional treatments. Thus, the search for new antibiofilm agents for medical purposes, especially of natural origin, is currently the object of much attention. The objective of the study presented here was to explore the potential of extracts derived from three seaweeds: the green Ulva lactuca, the brown Stypocaulon scoparium, and the red Pterocladiella capillacea, in terms of their antibiofilm activity against P. aeruginosa. After preparation of extracts by successive maceration in various solvents, their antibiofilm activity was evaluated on biofilm formation and on mature biofilms. Their inhibition and eradication abilities were determined using two complementary methods: crystal violet staining and quantification of adherent bacteria. The effect of active extracts on biofilm morphol. was also investigated by epifluorescence microscopy. Results revealed a promising antibiofilm activity of two extracts (cyclohexane and Et acetate) derived from the green alga by exhibiting a distinct mechanism of action, which was supported by microscopic analyses. The Et acetate extract was further explored for its interaction with tobramycin and colistin. Interestingly, this extract showed a promising synergistic effect with tobramycin. First analyses of the chem. composition of extracts by GC-MS allowed for the identification of several mols. Their implication in the interesting antibiofilm activity is discussed. These findings suggest the ability of the green alga U. lactuca to offer a promising source of bioactive candidates that could have both a preventive and a curative effect in the treatment of biofilms. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application In Synthesis of 2,4-Di-tert-butylphenol
The Article related to seaweed extract antibiofilm agent pseudomonas, pseudomonas aeruginosa, ulva lactuca, anti-biofilm, biofilm-matrix, seaweed extracts, synergistic activity, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Application In Synthesis of 2,4-Di-tert-butylphenol
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