Teng, Xingxing; Wang, Yuanyuan; Gu, Jinhua; Shi, Peiqi; Shen, Zhibin; Ye, Lianbao published an article in 2018, the title of the article was Antifungal agents: design, synthesis, antifungal activity and molecular docking of phloroglucinol derivatives.Recommanded Product: 55743-13-0 And the article contains the following content:
Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1-C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Mol. docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Min. Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clin. value. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 55743-13-0
The Article related to trichophyton phloroglucinol derivative antifungal mol docking, allylamine, antifungal activity, molecular docking, phloroglucinol derivatives, squalene epoxidase, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 55743-13-0
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