On May 27, 2010, Carruthers, Nicholas I.; Shireman, Brock T.; Tran, Vi T.; Wong, Victoria D.; Jablonowski, Jill A.; Chai, Wenying published a patent.Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Azetidine derivatives and related compounds as serotonin receptor modulators and their preparation and use in the treatment of serotonin-mediated diseases. And the patent contained the following:
The azetidines and related compounds of formula I are serotonin modulators useful in the treatment of serotonin-mediated diseases. Compounds of formula I wherein R1 is H, C1-4 alkyl, monocyclic cycloalkyl, Ph and benzyl; A is (CHR2)n; B is (CHR3)m; m is 1, 2, and 3; n is 1 and 2; with proviso that if m is 2, then n is not 1; R2 and R3 are independently H and C1-4 alkyl; R4 is H, F, C1-4 alkyl; or R4 is OH when L is CH2, CF2, CHF, OCH2 and OCHCH3; L is O, CH2, OCH2, OCHCH3, CH2O, CF2, and CHF; Z is O, CO, OCH2, etc.; R5 is (un)substituted Ph, (un)substituted phenoxy, (un)substituted naphthyl, etc.; X is C and N; R6 and R7 are independently H, halo, CF3, thienyl, and CONH2 and derivatives; and pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their serotonin receptor modulatory activity (data given). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to azetidine related compound preparation serotonin receptor modulator treatment disease, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol
Referemce:
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