Lopez-Ortiz, Carlos; Edwards, Mary; Natarajan, Purushothaman; Pacheco-Valenciana, Armando; Nimmakayala, Padma; Adjeroh, Donald A.; Sirbu, Cristian; Reddy, Umesh K. published an article in 2022, the title of the article was Peppers in Diet: Genome-Wide Transcriptome and Metabolome Changes in Drosophila melanogaster.Quality Control of 2,3-Dihydroxypropanoic acid And the article contains the following content:
The habanero pepper (Capsicum chinense) is an increasingly important spice and vegetable crop worldwide because of its high capsaicin content and pungent flavor. Diets supplemented with the phytochems. found in habanero peppers might cause shifts in an organism’s metabolism and gene expression. Thus, understanding how these interactions occur can reveal the potential health effects associated with such changes. We performed transcriptomic and metabolomic analyses of Drosophila melanogaster adult flies reared on a habanero pepper diet. We found 539 genes/59 metabolites that were differentially expressed/accumulated in flies fed a pepper vs. control diet. Transcriptome results indicated that olfactory sensitivity and behavioral responses to the pepper diet were mediated by olfactory and nutrient-related genes including gustatory receptors (Gr63a, Gr66a, and Gr89a), odorant receptors (Or23a, Or59a, Or82a, and Orco), and odorant-binding proteins (Obp28a, Obp83a, Obp83b, Obp93a, and Obp99a). Metabolome anal. revealed that campesterol, sitosterol, and sucrose were highly upregulated and azelaic acid, Et phosphoric acid, and citric acid were the major metabolites downregulated in response to the habanero pepper diet. Further investigation by integration anal. between transcriptome and metabolome data at gene pathway levels revealed six unique enriched pathways, including phenylalanine metabolism; insect hormone biosynthesis; pyrimidine metabolism; glyoxylate, and dicarboxylate metabolism; glycine, serine, threonine metabolism; and glycerolipid metabolism In view of the transcriptome and metabolome findings, our comprehensive anal. of the response to a pepper diet in Drosophila have implications for exploring the mol. mechanism of pepper consumption. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Quality Control of 2,3-Dihydroxypropanoic acid
The Article related to transcriptome metabolome metabolite phytochem drosophila diet capsaicin capsicum, drosophila, diet, habanero pepper, metabolome, transcriptome, Nonmammalian Biochemistry: Classical Genetics and Phylogeny and other aspects.Quality Control of 2,3-Dihydroxypropanoic acid
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