On June 23, 2005, Scott, Ian L.; Ralph, Jeffrey M.; Voss, Matthew E. published a patent.Synthetic Route of 72364-46-6 The title of the patent was Pharmaceutical compositions containing vinca alkaloid derivatives. And the patent contained the following:
The present invention relates to the preparation of derivatives of vinca alkaloids, I (R1 = alkyl, alkenyl, alkynyl, aryl, heterocycle, halogen, CN, CHO, ester, amide, sulfate, sulfonyl, amine, sulfide, borate, etc.; R2 = alkyl, or CHO, R3 = H, alkyl, oar c(O)R5, R4 = H, C(O)R5; R5, R6, R7 = independently alkyl, alkenyl, alkynyl, aryl, or heterocycle; R8 = H, halogen, alkyl, alkenyl, alkynyl, aryl, heterocycle, acyl, or thioalkyl; R9 = Ph, R10 = H or R9 and R10 together form a bridging double bond; R5, and R6 could form a ring or R6 and R7 could form a ring; X = ether, amine hydrazine, OH, etc.) for the treatment of various conditions. Thus, 12′-bromovincristine, cesium carbonate and Ph boronic acid were mixed in 1,4-dioxane and then treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) to give II, which displayed a GI50 of 50 and 30 nM in HeLa and MCF-7 cells resp. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Synthetic Route of 72364-46-6
The Article related to vinca alkaloid vinblastine vincristine derivative preparation, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Synthetic Route of 72364-46-6
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