On December 2, 2004, Laufer, Stefan A.; Zimmermann, Werner; Ruff, Kathrin J. published an article.Category: alcohols-buliding-blocks The title of the article was Tetrasubstituted Imidazole Inhibitors of Cytokine Release: Probing Substituents in the N-1 Position. And the article contained the following:
Novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity were prepared by a previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound I that potently inhibited the p38 mitogen-activated protein kinase (p38 IC50 = 0.218 μM) as well as the release of the proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα) from human whole blood after stimulation with LPS. Furthermore, I exhibited reduced cytochrome P 450 interaction in comparison with SB203580. This result is particularly important, since cytochrome P 450 interaction is observed for some p38 inhibitors and in turn can potentially cause drug-drug interaction or lead to other hepatic changes such as P 450 enzyme induction. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Category: alcohols-buliding-blocks
The Article related to imidazole tetrasubstituted preparation cytokine inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: alcohols-buliding-blocks
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