On September 18, 2014, Desroy, Nicolas; Heckmann, Bertrand; Brys, Reginald Christophe Xavier; Joncour, Agnes; Peixoto, Christophe; Bock, Xavier published a patent.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of imidazo[1,2-a]pyridine derivatives for treatment of inflammatory disorders. And the patent contained the following:
Disclosed are the title imidazo[1,2-a]pyridine derivatives I [R1a = H, halo, C1-C4 alkyl; R1b = halo, halo-(un)substituted C1-C4 alkyl, halo-(un)substituted C1-C4 alkoxy; X = S, O, N:CH, CH:CH; W = N, CR3; R4 = C1-C4 alkyl; R5 = (un)substituted C1-C4 alkyl with CN, OH, halo, C(:O)NH2; one of R6a or R6b = H, Me, halo, and the other is H; Cy = C4-C10 cycloalkyl, 41̃0 membered mono.bicyclic heterocycloalkyl, 47̃ membered heterocycloalkenyl; R7 = independently OH, oxo, halo, etc.; subscript a = 0, 1, 2; R8 = (L1-W1)m-L2-G1 wherein L1 = absent, O, C(:O), SO2, etc.; W1 = C1-C4 alkylene; subscript m = 0, 1; L2 = absent, O, C(:O), OC(:O), etc.; G1 = H, CN, (un)substituted C1-C4 alkyl, etc.; a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof; or a biol. active metabolite thereof] for treatment of inflammatory disorders. For example, II was prepared in a multistep synthesis. The present invention relates to compounds I inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions, and methods of treatment using I, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatol. disorders, and/or abnormal angiogenesis associated diseases by administering I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride
The Article related to preparation imidazopyridine treatment inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride
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