Electric Literature of 627-30-5 ,Some common heterocyclic compound, 627-30-5, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 10 2-(3-Chloropropoxy)tetrahydropyran To a solution of 3-chloropropanol (20.00 g, 0.212 mol) in dichloromethane (100 mL) 3,4-dihydro-2H-pyran (16.02 g, 0.190 mol) diluted in dichloromethane (17 mL) is added dropwise at 0-5C. The mixture is stirred for 30 minutes and the reaction (checked by TLC analysis) is quenched by washing with saturated sodium bicarbonate (100 mL). After separation the organic layer is washed with water (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure at 30C (34.32 g). The title compound is isolated by column chromatography on silica gel eluding with n-hexane:ethyl acetate) (31.28 g, 0.175 mol, 91%). 1H-NMR {300 MHz, CDCl3, delta (ppm)}: 1.2-2.0 (6H); 2.09 (m, 2H, CH2); 3.56 (m, 2H, Cl-CH2); 3.70 (m, 2H, O-CH2); 3.92 (m, 2H, O-CH2); 4.65 (m, 1 H, O-CH-O). GC-MS (El): [M-H]+ = 177; [M-ClCH2CH2CH2O]+ = 85
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,627-30-5, its application will become more common.
Reference:
Patent; Newchem S.p.A.; EP2019114; (2009); A1;,
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