On October 31, 2020, Yamamoto, Yukino; Hagura, Yoshio; Kawai, Kiyoshi published an article.Formula: C12H24O11 The title of the article was Freeze-concentrated glass-like transition temperature of carbohydrate-phosphate buffered saline systems and impact on collapse of freeze-dried solids. And the article contained the following:
Abstract: Phosphate buffered saline (PBS) and carbohydrates are used to freeze-dried biomaterials. It has been suggested that PBS reduces the freeze-concentrated glass-like transition temperature (T’g) of carbohydrate solutions and that freeze-dried solids collapse readily during freeze-drying. In order to obtain more insight into the subject, the effect of PBS on the T’g of trehalose solution was systematically investigated. The T’g of trehalose solution was found to be independent of the trehalose content. The T’g of trehalose-PBS solution, on the other hand, decreased with decreasing trehalose content. The behavior was described as a T’g curve for a trehalose-PBS pseudobinary system. The T’g curve was analyzed using the modified Gordon-Taylor equation, and the T’g of PBS was extrapolated to be 195.0 K. In order to compare the plasticizing effect of PBS, the T’g values of other carbohydrate materials including sugar alcs. (glucose, maltitol, sucrose, inulin, and maltodextrin) were also investigated. It was found that freeze-concentrated trehalose was more sensitive to the plasticizing effect of PBS than the other sugars. Finally, trehalose and trehalose-PBS solutions with varying trehalose content were freeze-dried, and their water activity (aw) and apparent volume ratio against pre-dried (frozen) solids (VFDVF-1) were evaluated. Freeze-dried trehalose samples had low aw values and high VFDVF-1 values. Freeze-dried trehalose-PBS samples, on the other hand, had significantly higher aw values and lower VFDVF-1 values than freeze-dried trehalose samples depending on the trehalose content. These results corresponded to the T’g and initial solute content. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Formula: C12H24O11
The Article related to carbohydrate phosphate buffered saline system freeze drying transition temperature, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Formula: C12H24O11
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