Dufour, Jeremy; Neuville, Luc; Zhu, Jieping published an article in 2010, the title of the article was Intramolecular Suzuki-Miyaura reaction for the total synthesis of signal peptidase inhibitors, arylomycins A2 and B2.Name: H-Phg(4-OH)-OH And the article contains the following content:
Development of the total syntheses of arylomycins A1 and B2 is detailed. Key features of our approach include (1) formation of 14-membered meta,meta-cyclophane by an intramol. Suzuki-Miyaura reaction; (2) incorporation of N-Me-4-hydroxyphenylglycine into the cyclization precursor, which avoids the late-stage low-yielding N-methylation step; (3) segment coupling of a fully elaborated peptide side chain to the macrocycle, which makes the synthesis highly convergent. Overall, arylomycin A2 was obtained in 13 steps from L-Tyr for the longest linear sequence, in 13 % overall yield. Arylomycin B2 was synthesized in 10 steps from L-3-nitro-Tyr, in 10 % overall yield. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Name: H-Phg(4-OH)-OH
The Article related to cyclic peptide arylomycin total synthesis signal peptidase inhibitor rotamer, suzuki miyaura coupling methylhydroxyphenylglycine cyclization peptide coupling, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Name: H-Phg(4-OH)-OH
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