On November 15, 2019, Wong, Nicholas; Petronijevic, Filip; Hong, Allen Y.; Linghu, Xin; Kelly, Sean M.; Hou, Haiyun; Cravillion, Theresa; Lim, Ngiap-Kie; Robinson, Sarah J.; Han, Chong; Molinaro, Carmela; Sowell, C. Gregory; Gosselin, Francis published an article.HPLC of Formula: 32462-30-9 The title of the article was Stereocontrolled synthesis of arylomycin-based gram-negative antibiotic GDC-5338. And the article contained the following:
We report herein an efficient, stereocontrolled, and chromatog.-free synthesis of the novel broad spectrum antibiotic GDC-5338. The route features the construction of a functionalized tripeptide backbone, a high-yielding macrocyclization via a Pd-catalyzed Suzuki-Miyaura reaction, and the late-stage elaboration of key amide bonds with minimal stereochem. erosion. Through extensive reaction development and anal. understanding, these key advancements allowed the preparation of GDC-5338 in 17 steps, 15% overall yield, >99 A % HPLC, and >99:1 dr. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9
The Article related to peptide antibiotic arylomycin based gdc5338 stereocontrolled synthesis crystal structure, tripeptide macrocyclization suzuki miyaura reaction palladium catalyst, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.HPLC of Formula: 32462-30-9
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