Wang, Guqi et al. published their patent in 2012 |CAS: 78-26-2

The Article related to alkyl nitrate ester nitric oxide prodrug muscular dystrophy treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

On December 5, 2012, Wang, Guqi; Lu, Qi Long published a patent.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula I wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ON02, CH2ONO2, Cn H2n +1OH, Cn H2n +1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n”” ≤ 9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ON02, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to alkyl nitrate ester nitric oxide prodrug muscular dystrophy treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

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