On May 12, 2011, Conn, P. Jeffrey; Lindsley, Craig W.; Hopkins, Corey R.; Weaver, Charles David; Niswender, Colleen M.; Cheung, Yiu-Yin published a patent.Formula: C7H7FS The title of the patent was Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. And the patent contained the following:
The present invention relates to (hetero)aryl sulfone compounds which are useful as allosteric potentiators/pos. allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4), synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, for example, in treating neurol. and psychiatric disorders or other diseases associated with glutamate dysfunction. Preparation of 5-(2-chlorobenzylsulfonyl)-2-(pyridin-2-yl)-1H-benzo[d]imidazole was exemplified (yield 59%). The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Formula: C7H7FS
The Article related to aryl sulfone preparation mglur4 receptor potentiator neurol psychiatric disease, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C7H7FS
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