On October 31, 2021, Qiu, Qianqian; Wang, Yanjuan; Gu, Guolong; Yu, Fan; Zhang, Shichao; Zhao, Yining; Ling, Bai published an article.Related Products of 621-37-4 The title of the article was Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene. And the article contained the following:
Farnesoid X receptor (FXR) has been considered as an attractive target for metabolic disorder and liver injury, while many current FXR agonists suffer from undesirable side effects, such as pruritus. Therefore, it is urgent to develop new structure types different from current FXR agonists. In this study, a series of structural optimizations were introduced to displace the unstable coumarin and geraniol scaffolds of auraptene (AUR), a novel and safe FXR agonist. All of these efforts led to the identification of compound 14 (I), a potent FXR agonist with nearly fourfold higher activity than AUR. Mol. modeling study suggested that compound 14 fitted well with binding pocket, and formed the key ionic bond with His291 and Arg328. In acetaminophen-induced acute liver injury model, compound 14 exerts better therapeutic effect than that of AUR, which highlighting its pharmacol. potential in the treatment of drug-induced liver injury. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4
The Article related to auraptene fxr agonist design synthesis, fxr, n-acetyl-p-aminophenol, Terpenes and Terpenoids: Monoterpenes (C10), Including Cannabinoids, Chrysanthemic Acids, and Iridoid Aglycons and other aspects.Related Products of 621-37-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts