On August 30, 2007, Vanotti, Ermes; Martina, Katia; Menichincheri, Maria; D’Alessio, Roberto published a patent.Quality Control of 1-(3-Fluoropyridin-4-yl)ethanol The title of the patent was Preparation of pyrrolopyrrolones as kinase inhibitors for treating cancer and other diseases. And the patent contained the following:
Compounds represented by formula I (wherein A is pyridin-4-yl, 3-fluoropyridin-4-yl, and 2-aminopyrimidin-4-yl; R1 is H, halo, and (C1-C6)alkyl; R2 is H, (C1-C6)alkyl, (C2-C6)alkenyl, etc.; R3 and R4 are H, (C1-C6)alkyl, (C3-C6)cycloalkyl, etc., or taken together form a (C3-C6)cycloalkyl), compositions thereof, and methods of use thereof. I are useful, in therapy, as agents against a host of diseases caused by and/or associated to a disregulated protein kinase activity and more particularly, Cdk2 and Cdc7 activity. I have protein kinase inhibiting activity and more particularly, Cdk2 and Cdc7 inhibiting activity; no biol. data is given in the patent. Example compound II was synthesized by cyclization of DL-2-(1-Amino-2-benzyloxyethyl)-5-(2-aminopyrimidin-4-yl)-1H-pyrrole-3-carboxylic acid. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).Quality Control of 1-(3-Fluoropyridin-4-yl)ethanol
The Article related to pyrrolopyrrolone preparation kinase inhibitor cancer other disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 1-(3-Fluoropyridin-4-yl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts