On June 21, 2012, Surman, Matthew D.; Guzzo, Peter R.; Freeman, Emily; Henderson, Alan J. published a patent.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of tetrahydro-azacarboline MCH-1 antagonists. And the patent contained the following:
The present invention relates to tetrahydro-azacarboline derivatives I [G = NR8CR9C10 or CR9R10NR8; X = CR16, C(R16)2, N, NR16; Y = CR16, C, N; W = C or N; Q = C or N; Z = C, CH or N; L = (CH2)pO, (CH2)p, CH:CH, a bond; A = C, CH, CH2, N; B = (un)substituted (hetero)aryl, heterocyclyl, cycloalkyl; R1 = H, alkyl, cycloalkyl, etc.; R2-R5, R9-R10 = H, halo, alkyl, etc.; R6 = H, halo, aryl, etc.; R7 = H, halo, CN, etc.; R8 = H, alkyl, cycloalkyl, etc.; n = 0-3; p = 1-4] which are melanin-concentrating hormone (MCH-1) receptor antagonists. Twenty-eight compounds I were prepared E.g., a multi-step synthesis of II.HCl, starting from 2,6-dibromopyridine, was described. Exemplified compounds I were tested in the human MCH-1 binding assay (data given). The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to azacarboline preparation melanin concentrating hormone mch1 receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts