Application of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of 2-(2-aminoethoxy)ethanol (99.52 g) and ethyl acetate (200 mL) was added dropwise a mixture of di-tert-butyl dicarbonate (208.57 g) and ethyl acetate (50 mL) under ice-cooling. The reaction solution was stirred at room temperature for 60 hrs, and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (500 mL), and washed with water (200 mL), 1 N hydrochloric acid (200 mL), water (300 mL), and saturated brine (300 mL), followed by drying over anhydrous sodium sulfate. The solution was concentrated under reduced pressure to give tert-butyl [2-(2-hydroxyethoxy)ethyl]carbamate as colorless oil (169.2 g).1 H-NMR (cdcl3) : 1.45 (9H,s), 3.33(2H,q,J=5.1Hz), 3.54-3.59(4H,m), 3.74 (2H, q, J=5. 1Hz), 4.88(2H,bs).
The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
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