On January 31, 2022, Vahdati, Saeed Niazi; Lashkari, Ali; Navasatli, Sepideh Aliniaye; Ardestani, Susan Kabudanian; Safavi, Maliheh published an article.Electric Literature of 96-76-4 The title of the article was Butylated hydroxyl-toluene, 2,4-Di-tert-butylphenol, and phytol of Chlorella sp. protect the PC12 cell line against H2O2-induced neurotoxicity. And the article contained the following:
Oxidative stress is considered the main cause of cellular damage in a number of neurodegenerative disorders. One suitable ways to prevent cell damage is the use of the exogenous antioxidant capacity of natural products, such as microalgae. In the present study, four microalgae extracts, isolated from the Persian Gulf, were screened to analyze their potential antioxidant activity and free radical scavenging using ABTS, DPPH, and FRAP methods. The methanolic extracts (D1M) of green microalgae derived from Chlorella sp. exhibited potent free radical scavenging activity. In order to characterize microalgae species, microscopic observations and anal. of the expression of 18S rRNA were performed. The antioxidant and neuroprotective effects of D1M on H2O2-induced toxicity in PC12 cells were investigated. The results demonstrated that D1M significantly decreased the release of nitric oxide (NO), formation of intracellular reactive oxygen species (ROS), and the level of malondialdehyde (MDA), whereas it enhanced the content of glutathione (GSH), and activity of heme oxygenase 1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), and catalase (CAT) in PC12 cells exposed to H2O2. The pretreatment of D1M improved cell viability as measured by the MTT assay and invert microscopy, reduced cell apoptosis as examined by flow cytometry anal., increased mitochondrial membrane potential (MMP), and diminished caspase-3 activity. The GC/MS anal. revealed that D1M ingredients have powerful antioxidant and anti-inflammatory compounds, such as butylated hydroxytoluene (BHT), 2,4-di-tert-butyl-phenol (2,4-DTBP), and phytol. These results suggested that Chlorella sp. extracts have strong potential to be applied as neuroprotective agents, for the treatment of neurodegenerative disorders. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4
The Article related to phytol butylated hydroxyl toluene hydrogen peroxide butylphenol chlorella neurotoxicity, anti-inflammatory, antioxidant, chlorella sp, microalgae, neuroprotective, pc12 cell and other aspects.Electric Literature of 96-76-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts