On March 10, 2021, Lesch, Bernhard; Jakob, Florian; Pletinckx, Katrien; Arndt, Verena; Wagener, Markus; Dunkern, Torsten published a patent.Electric Literature of 386704-04-7 The title of the patent was Preparation of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators. And the patent contained the following:
The invention relates to compounds of formula I which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2 which include but are not limited to inflammatory and autoimmune diseases, diabetes, obstructive airway disorders, sepsis, etc. Compounds of formula I [wherein X1 = CH2, or C(O) and X2 = CH2; or X2 = CH2 or C(O) and X1 = CH2; R1 = Ph or 5 or 6-membered heteroaryl; Z = 5 or 6-membered heteroaryl which mono-, di, or trisubstituted with R2; each R2 independently = H, F, Cl, CF3, etc.; L = bond, C1-6alkylene, C(O), S(O)2, etc.; R3 = H, C1-6alkyl, C3-6cycloalkyl, 3-to 6-membered heterocycloalkyl, etc.; wherein C1-6alkyl in each case independently from one another is linear or branched, saturated or unsaturated; wherein C1-6alkylene is linear and saturated or unsaturated; wherein C1-6alkyl, C1-6alkylene, C3-6cycloalkyl, and 3 to 6-membered heterocycloalkyl in each case independently from one another are unsubstituted or mono- or polysubstituted; with proviso] in form of free compounds or physiol. acceptable salts thereof, are claimed and exemplified. Example compound II was synthesized from the reaction of prepared intermediate trans-1-(4-chloro-phenyl)-3-(6′-methoxy-1,2,3,4,5,6-hexahydro-3,3′-bipyridinyl-4-yl)-urea hydrochloride with 4-iodo-pyrimidine in the presence of L-proline and CuI in 14% yield. Candidate compounds of formula I were evaluated for agonistic activity using hFPR2-Aq-CHO cells from which II demonstrated an EC50 = 0.00600μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Electric Literature of 386704-04-7
The Article related to piperidine urea heteroaryl derivative preparation fpr2 inflammatory autoimmune disease, piperidone urea heteroaryl derivative preparation diabetes obstructive airway disorder and other aspects.Electric Literature of 386704-04-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts