Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias published an article in 2016, the title of the article was Iron-Catalyzed Reaction of Urea with Alcohols and Amines: A Safe Alternative for the Synthesis of Primary Carbamates.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol And the article contains the following content:
A general study of the iron-catalyzed reaction of urea with nucleophiles is here presented. The carbamoylation of alcs. allows for the synthesis of N-unsubstituted (primary) carbamates, including present drugs (Felbamate and Meprobamate), without the necessity to apply phosgene and related derivatives Using amines as nucleophiles gave rise to the resp. mono- and disubstituted ureas via selective transamidation reaction. These atom-economical transformations provide a direct and selective access to valuable compounds from cheap and readily available urea using a simple Lewis-acidic iron(II) catalyst. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol
The Article related to primary carbamate urea preparation green chem, urea alc amine carbamoylation transamidation iron catalyst, catalysis, iron, nucleophilic substitution, primary carbamates, urea and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts